What should I know about Viibryd before taking it?

Before taking the antidepressant Viibryd (vilazodone), talk to your doctor about how to take the drug safely, what side effects and interactions to be aware of and what to expect of your treatment.

You may notice some depression relief within a week or two of beginning Viibryd, but it may take as long as six weeks for most of your depression symptoms to improve.

Be patient and don't stop taking the drug or change the dose without checking with your doctor. Stopping Viibryd abruptly may cause uncomfortable effects, such as nausea, headache, dizziness and irritability.

Initially, you may have unexpected thoughts and emotions. Let your doctor know immediately if these are troublesome, if your symptoms become worse or new ones occur, or if you have suicidal thoughts.

Since Viibryd may make you sleepy or affect your thinking and ability to respond quickly, don't drive or do anything that could be dangerous until you know how you are reacting to the drug.

Harmful interactions with other conditions are possible, so let your doctor know your complete medical and psychological history. Especially important are:

  • liver problems
  • kidney ailments
  • bleeding issues
  • seizures
  • manic depression or bipolar disorder, or mania
  • low sodium blood levels

Since some drugs may not mix well with Viibryd, give your doctor a list of medications that you take, including prescription and nonprescription drugs, and herbal remedies. Especially important are:

  • other antidepressants
  • anti-anxiety drugs
  • triptans (Imitrex)
  • antibiotics
  • antifungals
  • HIV medications
  • pain medications, such as tramadol (Ultram) and meperidine (Demerol)
  • St. John's wort
  • nonsteroidal anti-inflammatory drugs (NSAIDS), such as aspirin or ibuprofen (Motrin)
  • blood thinners, such as warfarin (Coumadin)
  • antiseizure medications such as mephenytoin (Mesantoin)
  • diuretics
  • blood pressure medications, such as verapamil (Calan) or Diltiazem (Cardizem)
  • Monoamine oxidase inhibitors (MAO inhibitors), such as phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), and selegiline (Eldepryl, Emsam, Zelapar).

Tell your doctor about any habits or situations that may affect or be affected by Viibryd. For example, let your doctor know if you:

  • drink alcohol
  • use any recreational drugs 
  • are pregnant or plan to become pregnant
  • are breastfeeding
  • are in psychotherapy 
  • are being treated for substance abuse

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.