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What should I know before taking tricyclic antidepressants?

Donna Hill Howes, RN
Family Practitioner

Some tricyclic antidepressants may not be safe or effective for children and adolescents. Consult individual drug labels.

If you have cardiovascular disease, tricyclic antidepressants can lead to serious side effects and should be avoided.

If you have seizure disorder (epilepsy), an enlarged prostate (BPH), glaucoma, urinary retention, or hyperthyroidism, a tricyclic antidepressant may not be a good option for you.

If you are pregnant, planning a pregnancy, or may be pregnany, tricyclic antidepressants may be risky. The health of your baby may be at risk if you take tricyclic antidepressants.

Tricyclic antidepressants are or may be passed into breast milk. They may not be good options if you are breastfeeding. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.