What are dual reuptake inhibitors?

The dual reuptake inhibitors venlafaxine (Effexor) and duloxetine (Cymbalta) are a class of antidepressants that block the reuptake of both serotonin and norepinephrine. To a lesser degree, they also block the reabsorption of dopamine. Venlafaxine and duloxetine are prescribed for generalized anxiety disorder and post-traumatic stress disorder, either initially or when selective serotonin reuptake inhibitors (SSRIs) aren't effective or cause intolerable side effects.

Like SSRIs, however, these medications can exacerbate sleep problems and cause nausea and headache. Effexor XR, the extended-release form of venlafaxine, has fewer side effects than the shorter-acting version. For example, it doesn't cause nausea. Plus it is taken just once a day. However, Effexor XR is not approved for children or teens.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.