Is taking Paxil with Zomig safe?

There is a possibility that controlling your anxiety may lessen the frequency of your migraines and therefore reduce or eliminate your need to take the Zomig. There is a risk and a major potential drug interaction between the Zomig and the Paxil if taken together. Both of these medicines increase the amount of serotonin in the brain and can cause a rare but serious reaction called serotonin syndrome. However, because Zomig is taken as needed for migraines, the risk of serotonin syndrome while on these two medicines is low. Using the lowest dose of Paxil and Zomig that improves your conditions/symptoms can further reduce your risk of serotonin syndrome. Although serotonin syndrome is a rare condition, you should be aware of the symptoms and seek medical attention immediately if any of them occur. Symptoms of serotonin syndrome include:

  • agitation or restlessness
  • confusion
  • rapid heart rate
  • dilated pupils
  • loss of muscle coordination or twitching muscles
  • heavy sweating
  • diarrhea
  • headache
  • shivering
  • goose bumps

Many patients take this combination of medicines without experiencing serious side effects. If you are still concerned about the interaction, you should follow up with your treating doctor to discuss your concerns and review the risk versus benefit of starting Paxil therapy if you are continuing with the Zomig.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.