Will protriptyline interact with other drugs I take?

Protriptyline may interact with many different drugs, so make sure that your doctor knows about all drugs that you are currently taking to avoid potentially dangerous interactions. There are many drugs that could interact with protriptyline, but that can still be used as long as your doctor is watching you carefully; an example of this is the class of drugs known as ACE inhibitors. However, the interaction of protriptyline with any of the following drugs is so serious that you should not be on them while on protriptyline. These drugs are:

  • artemether
  • dronedarone
  • iobenguane I 123
  • lumefantrine
  • MAO inhibitors
  • nilotinib
  • pimozide
  • quinine
  • thioridazine
  • ziprasidone

Many of these drugs, when taken in combination with protriptyline, can lead to dangerous heart rhythm abnormalities; others can cause a dangerous condition called serotonin syndrome.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.