Does protriptyline interact with other medications?

Protriptyline can interact with other medications, and should never be taken within 14 days of monoamine oxidase inhibitors (MAOIs). Doing so increases the risk for life-threatening side effects. Other medications that may interact with protriptyline include: azole antifungals, barbiturate drugs, blood pressure medications, decongestants, antispasmodic drugs, epinephrine and norepinephrine, narcotic painkillers, cimetidine, duloxetine, flecainide, methylphenidate, phenothiazines, propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs), other antidepressants, tranquillizers and sleep medications and terbinafine. Protriptyline should not be taken with the following medications: droperidol, furazolidone, pimozide, quinolone antibiotics, streptogramins, tramadol and ziprasidone.

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