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How does paroxetine CR interact with other medications?

Paroxetine CR should not be combined with pimozide, thioridazine, or monoamine oxidase inhibitors (MAOIs). You will need to wait at least 14 days after taking an MAOI before you can take this drug.

Do not take any sedative medicine, including drugs for pain, cold or allergy, arthritis, fever, insomnia, seizures, or swelling, without telling your doctor first. Drugs that are known to cause problems when combined with paroxetine CR are blood thinners, St. John's wort, tramadol, heart medication such as digoxin and quinidine, tryptophan, tamoxifen, other antidepressants, drugs for psychiatric disorders such as lithium, linezolid, cimetidine, fosamprenavir, almotriptan, frovatriptan, naratriptan, zolmitriptan, sumatriptan, and theophylline. There may be other drugs that can interact with paroxetine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

There are no known food interactions with paroxetine CR. Avoid drinking alcohol, which can increase some of the side effects.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.