Does milnacipran HCl interact with other drugs?

Milnacipran HCl (hydrochloride) can interact with a number of other prescription drugs. You should not take milnacipran HCl if you have taken a monoamine oxidase inhibitor (MAOI) within the past two weeks. Life-threatening drug interactions could occur. Talk to your doctor before taking milnacipran HCl if you are taking any of the following:

  • anticoagulants
  • diuretics
  • clonidine
  • digoxin
  • epinephrine
  • tramadol
  • lithium
  • tryptophan
  • drugs for migraine headaches
  • antidepressants
  • non-steroidal anti-inflammatory drugs, including aspirin and ibuprofen
  • duloxetine
  • clompramine
  • sedatives, sleeping pills, or tranquilizers
  • narcotic pain medications
  • venlafaxine
  • muscle relaxers

You should avoid drinking alcohol while taking milnacipran HCl, since it can make side effects like drowsiness and dizziness worse. Talk to your doctor about any other prescription or over-the-counter drugs, vitamins, and supplements you are taking, especially cold, cough, and allergy remedies.

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