What should I know about milnacipran HCl before taking it?

Milnacipran HCl (hydrochloride) is not used as an antidepressant, but it carries the same risks as some forms. Children, adolescents, and young adults may become suicidal when taking serotonin and norepinephrine reuptake inhibitors, or SNRI, such as milnacipran HCl. Even if you are an adult over the age of 24, taking milnacipran HCl can cause mental health changes, including:

  • thoughts or plans of self-harm
  • new or worsened depression
  • anxiety
  • panic attacks
  • agitation
  • insomnia
  • aggression
  • irritability
  • restlessness
  • abnormal excitement
  • impulsivity

Talk to your doctor before taking milnacipran HCl if you have a history of depression, bipolar disorder, suicidal thoughts or behaviors, or heavy alcohol use. Talk to your doctor before taking milnacipran HCl if you have or have ever had:

  • glaucoma
  • high blood pressure
  • seizures
  • irregular heartbeat
  • inflamed or enlarged prostate
  • difficulty urinating
  • a bleeding disorder
  • kidney, liver, or heart disease

If you must have surgery, no matter how minor, while taking milnacipran HCl, tell the surgeon or dentist that you are taking milnacipran HCl. If you are pregnant or breastfeeding, tell your doctor before taking milnacipran HCl. Talk to your doctor about taking milnacipran HCl if you are allergic to yellow food dye or aspirin. Milnacipran HCl may cause drowsiness. Do not drive or operate machinery until you know how it will affect you.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.