What should I know about amoxapine before taking it?

Like other antidepressants, amoxapine may increase the risk of suicidal thoughts or actions in children and young adults. Children, teenagers, or young adults who are taking amoxapine should be closely supervised for signs of increased suicidal behavior.

If such signs are detected, contact your doctor immediately. People taking monoamine oxidase inhibitors (MAOIs), clonidine, guanethidine, H1 antagonists or a macrolide or ketolide such as erythromycin should not take amoxapine, nor should people who have recently had a heart attack. Before starting amoxapine tell your doctor if you have a history of seizures or epilepsy, suicidal thoughts, glaucoma or other eye problems, prostate or urination problems, a blood disorder, thyroid or heart problems. Amoxapine can cause drowsiness or dizziness.

Avoid alcohol or medications that also cause drowsiness while taking amoxapine, and exercise extreme caution when deciding to drive or operate heavy machinery. Contact your doctor right away if you begin to develop uncontrollable muscle spasms or signs of neuroleptic malignant syndrome (these include irregular heart beat or pulse, altered mental state, and rigidity in the muscles).

Be aware also that amoxapine may cause sensitivity to sunlight. Some medications may interact with amoxapine and make side effects more severe. Tell your doctor if you are taking any of the following medications: antiarrhythmics; anticoagulants; carbamazepine; cimetidine; fluconazole; guanfacine; SSRIs; sympathomimetics such as albuterol, amphetamine, or pseudoephedrine; phenothiazines; quinixine; or terbinafine.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.