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Does imipramine interact with other medications?

Imipramine can interact with other medications, so it's important to talk to your doctor about any medications you are taking including cold medicines, muscle relaxers, and pain medication. When using some types of medications to treat certain health conditions, dosing of imipramine may have to be adjusted. Tell your doctor if you are using any of the following medications, especially within the last 5 weeks:

  • SSRI antidepressants such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft); cimetidine (Tagamet)
  • clonidine (Catapres)
  • guanethidine (Ismelin)
  • methylphenidate (Concerta, Ritalin, Daytrana)
  • heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), or quinidine (Cardioquin, Quinidex, Quinaglute)

It's important to talk to your doctor or pharmacist about other possible drug interactions with imipramine before beginning a new medication. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.