How is Tofranil different from SSRI antidepressants?

Stacy Wiegman, PharmD

Pharmacy

Tofranil (imipramine) is a tricyclic antidepressant, which is a class of medications older than SSRIs (selective serotonin reuptake inhibitors). Both types of antidepressants affect the balance of certain brain chemicals known as neurotransmitters to relieve depression symptoms. However, SSRIs tend to have fewer and less severe side effects. Both types of drugs are widely prescribed, and your doctor will help determine which type is best for you.

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