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How can I reduce the side effects of Savella?

You can reduce the side effects of the fibromyalgia drug Savella (milnacipran) by telling your doctor about every other drug (prescription and nonprescription), supplements and herbal remedies you currently take. To prevent a serious side effect known as serotonin syndrome, you should avoid taking a monoamine oxidase inhibitor (MAOI) for at least two weeks before starting Savella. Other drugs and supplements may also cause this life-threatening reaction if you take them with Savella. These include triptans, lithium, tryptophan, 5-HTP, St. John's wort, Tramadol, linezolid and antipsychotics. Do not take any new medication or supplement without talking to your doctor first.

Tell your doctor about any medical conditions you have or have had, including heart, liver or kidney problems, a history of seizures, blood pressure problems and narrow-angle glaucoma. This is important because some conditions may increase the risks of side effects. Drinking alcohol can also worsen Savella's side effects.

Take Savella exactly as directed by your doctor. Do not stop taking it without talking to your doctor first. Abruptly stopping may cause withdrawal symptoms.

Savella is a serotonin-norepinephrine reuptake inhibitor (SNRI), a medication associated with an increased risk for suicidal thoughts, behaviors or actions, especially in young adults, teenagers and children. While you can't eliminate this risk, you (and others around you) should watch for changes in mood or behavior including suicidal thoughts or behaviors, aggressive or violent behavior, anxiety, irritability, panic attacks, agitation, restlessness or trouble sleeping.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.