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How can I reduce the side effects of Remeron?

To reduce the side effects of the antidepressant Remeron (mirtazapine), tell your doctor about all the medicines (prescription or nonprescription), supplements and herbal remedies you take. One of Remeron's most serious side effects, known as serotonin syndrome, can occur when it interacts with certain other drugs or supplements, including monoamine oxidase inhibitors (MAOIs), triptans (used to treat migraines), St. John's wort, tryptophan, Tramadol, linezolid and other medicines to treat mental illness. Do not take any new medication or supplement without talking to your doctor first. Tell your doctor about any medical conditions you have or have had, including heart, liver or kidney problems, a history of seizures, convulsions, bipolar disorder or mania.

Take Remeron exactly as directed by your doctor. Do not stop taking it without talking to your doctor first, because stopping suddenly may cause withdrawal symptoms.

Remeron can interfere with your motor skills. To minimize this problem, avoid drinking alcohol or taking diazepam, since they can magnify this effect. Because sleepiness is very common while taking this medicine, it’s best to take it before bedtime.

Be sure to call your doctor right away at the first sign of any serious side effects, including:
  • changes in mood or behavior, including worsening depression, suicidal thoughts or behaviors, aggressive or violent behavior, anxiety, irritability, panic attacks, agitation, restlessness or trouble sleeping
  • signs of serotonin syndrome, including agitation, hallucination, loss of consciousness, high or low blood pressure, muscle twitching or stiffness, a racing heart, sweating, fever, vomiting or diarrhea
  • allergic reactions, such as breathing troubles, rash or hives, joint pain or swelling of the face, tongue, eyes or mouth
  • seizures
  • chest pain or fast heartbeat
  • severe skin reactions, including rash with swelling on the hands or feet, painful reddening of the skin and blisters in the mouth or on the body
  • signs of low sodium (salt) levels in the blood, including headache, weakness or feeling unsteady, mental confusion or memory problems
  • flu-like symptoms, such as fever, chills, sore throat and mouth sores

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.