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How is Paxil used to treat chronic headaches?

Paxil (paroxetine) may help prevent and treat headaches by adjusting levels of the chemical serotonin in the brain. One function of serotonin is to help regulate pain, and some research indicates that people who experience chronic headaches have low levels of serotonin at key spots in their brains. Making serotonin more available can increase feelings of well-being, which might also help alleviate headache pain. Paxil is approved by the Food and Drug Administration for treating depression in adults, but it is sometimes prescribed "off label" to treat chronic headaches.

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