How does nortriptyline interact with other medications or foods?

Donna Hill Howes, RN
Family Practitioner

If you are taking linezolid, you should not take nortriptyline.

Do not use nortriptyline if you are taking an MAO inhibitor. You should not take nortriptyline until at least 2 weeks after stopping MAO inhibitors.

If you are taking tedizolid or a drug that prolongs the QTc interval, nortriptyline can lead to serious side effects and should be avoided.

If you are taking a 5-HT3 antagonist, a beta-2 agonist, an antipsychotic, a central nervous system depressant drug, cinacalcet, desmopressin, lithium, methylphenidate, metoclopramide, metyrosine, mirabegron, an opioid, rufinamide, a selective serotonin reuptake inhibitor, topiramate, or tramadol, nortriptyline may not be a good option for you.

If you are taking abiraterone, an anticholinergic bronchodilator, eluxadoline, iobenguane I-123, or paraldehyde, nortriptyline can lead to side effects and should be avoided.

If you take nortriptyline, you should avoid kava kava and St. John's wort.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.