How does mirtazapine interact with other medications or alcohol?

Mirtazapine can interact with other drugs, herbal remedies and alcohol. You may experience increased drowsiness when taking cold or allergy medicine, narcotics, sleeping pills, muscle relaxers or other antidepressants while taking this medication.

Hydantoins and clonidine can make mirtazapine less effective, while fluvoxamine can increase its effects. Due to the risk of serotonin syndrome, mirtazapine should not be used in combination with MAO inhibitors or serotonin-precursors (such as oxitriptan and L-tryptophan). Mirtazapine should also be used with caution if you take serotonergic drugs (e.g., triptans, lithium, tramadol, St. John’s Wort and most tricyclic antidepressants). Inform your doctor if you are taking any of these medications before starting mirtazapine.

Other medications may also interact with mirtazapine. Talk to your doctor about any prescription, over-the-counter or herbal medications you are using before taking mirtazapine. In addition, you should avoid alcohol while on this medication, as it can increase dizziness and other side effects.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.