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How is desvenlafaxine (Pristiq) used?

The antidepressant desvenlafaxine (Pristiq) is usually taken by mouth only once daily. This is because it comes in an extended release (long-acting) tablet. Do not split, chew or crush the tablet. Desvenlafaxine works by affecting the neurotransmitters norepinepherine and serotonin in the brain. These neurotransmitters are known to be linked to mood and depression.

Desvenlafaxine is in the drug class called the selective serotonin and norepinephrine reuptake inhibitors.

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