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How effective are tricyclic antidepressants at treating migraines?

Donna Hill Howes, RN
Family Practitioner

Guidelines published by the American Headache Society state that amitriptyline is probably effective for migraine prevention. The guidelines do not mention other tricyclics. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.