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How effective is duloxetine for treating osteoarthritis?

Donna Hill Howes, RN
Family Practitioner

Research on duloxetine has found it to be about as effective as NSAIDs for improving pain and function in osteoarthritis. It appears to be about as effective as most opioids, and may be more effective than the opioids tramadol, oxycodone, and hydrocodone. But there is not enough research yet to be sure exactly how effective duloxetine is, or how it can best be used to treat osteoarthritis.

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