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How does duloxetine interact with other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking...

  • A 5-HT3 receptor antagonist, metaxalone, metoclopramide, paroxetine, a selective serotonin reuptake inhibitor, a serotonin-NE reuptake inhibitor, tedizolid, or a tricyclic antidepressant - Duloxetine can lead to serious side effects and should be avoided
  • Tthioridazine - Duloxetine can lead to side effects and should be avoided. Other antipsychotic drugs may not be good options for you
  • Apixaban, ibritumomab, ibrutinib, obinutuzumab, salicylate, tositumomab, or tramadol - Duloxetine may not be a good option for you
  • A strong CYP1A2 inhibitor, doxorubicin, eliglustat, iobenguane I-123, or metoprolol - Duloxetine can lead to side effects and should be avoided
  • Linezolid - You should not take duloxetine

You should not take duloxetine if you are taking an MAO inhibitor or until at least 14 days after stopping MAO inhibitors.

If you take duloxetine, you should avoid the herbals alfalfa, anise, and bilberry.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.