Does amoxapine interact with other drugs?

Amoxapine (Asendin) can be risky when mixed with certain drugs. Do not take amoxapine if you take or have taken medication belonging to a group of antidepressant drugs called monoamine oxidase (MAO) inhibitors. 
These drugs include isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar) and tranylcypromine (Parnate). Tell your doctor if you have taken an MAO inhibitor in the last two weeks. If you stop taking amoxapine, wait at least 14 days before you take an MAO inhibitor again.

Bring a list of your medications when you talk to your doctor. It should include prescription and nonprescription medications, vitamins, supplements and herbs. Make sure you discuss anticoagulants (blood thinners) such as warfarin (Coumadin), antihistamines, cimetidine (Tagamet), flecainide (Tambocor); levodopa (Sinemet, Larodopa), lithium (Eskalith, Lithobid), medications for high blood pressure, seizures, Parkinson's disease, asthma, colds or allergies, methylphenidate (Ritalin), muscle relaxants, propafenone (Rythmol), quinidine, sedatives, sleeping pills, thyroid medications and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

If you are being treated for depression, your doctor also needs to know if you take antidepressants, including drugs called selective serotonin reuptake inhibitors (SSRIs), such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft).

Continue Learning about Antidepressant

Are Antidepressants Safe to Take During Pregnancy?
Are Antidepressants Safe to Take During Pregnancy?
Research suggests that depression is diagnosed twice as often in women as it is in men, and it typically presents during a woman’s childbearing years....
Read More
Which common foods and drugs can interact dangerously with antidepressants?
Dr. Mehmet Oz, MDDr. Mehmet Oz, MD
The following information will provide the most common and easily avoided sources of adverse dru...
More Answers
What are the side effects of nortriptyline?
Donna Hill Howes, RNDonna Hill Howes, RN
Side effects may include drowsiness, lethargy, fatigue, weakness, dry mouth, eye and vision problems...
More Answers
What Is Treatment-Resistant Depression?
What Is Treatment-Resistant Depression?

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.