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Does paroxetine interact with other medications or foods?

Taking paroxetine with antipsychotics such as aripiprazole or risperidone can cause neuroleptic malignant syndrome (NMS), which can be fatal. Your risk of another potentially fatal condition, serotonin syndrome, is increased if you mix this drug with triptans or monoamine oxidase inhibitor drugs (MAOIs). Don't take St. John's Wort or linezolid at the same time you're taking this medication. Once you have stopped taking this drug, your doctor may tell you to wait several weeks before you begin taking any other drugs.
Anticoagulants, aspirins and nonsteroidal anti-inflammatory drugs may increase the risk of bleeding, including stomach bleeding, when combined with this drug. Diuretics may increase your risk of low blood sodium levels. Taking paroxetine may decrease the effectiveness of digoxin and tamoxifen. Antiarrhythmics and phenothiazines are not compatible since they may cause irregular heartbeat or heart problems. The effectiveness of paroxetine may be diminished if you also take phenobarbital, HIV protease inhibitors or cyproheptadine. You run a higher risk of side effects from the antidepressants, such as clozapine and fluoxetine when taken with this drug. Tell your doctor about all of the medications you are taking prior to starting treatment with this medication. There are no known food interactions.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.