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Do tricyclic antidepressants interact with any other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking any of the following medications, tricyclic antidepressants can lead to side effects and should be avoided:

  • abiraterone
  • azelastine nasal spray
  • bupropion
  • dabrafenib
  • doxylamine
  • fusidic acid
  • iobenguane I-123
  • ivabradine
  • naloxegol
  • orphenadrine
  • paraldehyde
  • potassium chloride in solid form
  • simeprevir
  • thalidomide

If you are taking an adrenergic beta-2 agonist, a central nervous system depressant drug, cinacalcet, desmopressin, doxorubicin, methylphenidate, metoprolol, metyrosine, mirabegron, an opioid, oxycodone, or topiramate, a tricyclic antidepressant may not be a good option for you.

If you are taking an anticholinergic drug, a tricyclic antidepressant may not be a good option for you. If you are taking aclidinium, ipratropium, tiotropium, or umeclidinium, tricyclics should be avoided.

If you are taking an antipsychotic drug, lithium, metoclopramide, a drug that prolongs the QTc interval, a serotonin reuptake inhibitor, tedizolid, or tramadol, tricyclic antidepressants can lead to serious side effects and should be avoided.

If you are taking cisapride, you should not take amitriptyline.

If you are taking linezolid, you should not take a tricyclic antidepressant.

If you are taking lomitapide, olaparib, pimozide, a tyrosine kinase inhibitor, ulipristal, or tolvaptan, desipramine can lead to side effects and should be avoided.

Tricyclic antidepressants should not be taken with MAO inhibitors or within 2 weeks of stopping MAO inhibitors.

If you take a tricyclic antidepressant, you should avoid kava kava and St. John's wort. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.