Can Tofranil interact with other medications or foods?

The antidepressant Tofranil (imipramine) may interact with several other medications: It's not recommended for people taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar) or tranylcypromine (Parnate), or for people who have taken one in the last 14 days.

Tell your doctor and pharmacist about every drug and supplement you take. In particular, if you take any of the following medications it may affect your dosage of Tofranil or mean you should be monitored carefully for side effects:
  • blood thinners such as warfarin (Coumadin)
  • antihistamines or asthma or cold medication
  • the antacid cimetidine (Tagamet)
  • heart medications for arrhythmia such as flecainide (Tambocor) and propafenone (Rythmol)
  • drugs for high blood pressure
  • Parkinson's medication such as levodopa (Sinemet, Larodopa)
  • mood stabilizers such as lithium (Eskalith, Lithobid)
  • selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft)
  • ADHD medication such as methylphenidate (Ritalin)
  • thyroid medications, muscle relaxants, tranquilizers, sleeping pills or drugs that treat nausea or seizures
If you’ve taken Prozac or Sarafem within the last five weeks, your doctor may tell you not to take Tofranil.

Tofranil isn't known to interact with any particular foods, but drinking alcohol while taking it can worsen drowsiness, a common side effect of the drug.

Continue Learning about Antidepressant

Are Antidepressants Safe to Take During Pregnancy?
Are Antidepressants Safe to Take During Pregnancy?
Research suggests that depression is diagnosed twice as often in women as it is in men, and it typically presents during a woman’s childbearing years....
Read More
How safe are tricyclic antidepressants for people with dementia?
Sarah N. Mourra, MDSarah N. Mourra, MD
Tricyclic antidepressants are used as second-line medications for depression in people with dementia...
More Answers
How long does it take for antidepressants to start working?
Michael D. Banov, MDMichael D. Banov, MD
In research studies that carefully measure when positive results from antidepressant therapy are see...
More Answers
What Is Treatment-Resistant Depression?
What Is Treatment-Resistant Depression?

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.