Advertisement

Can Tofranil interact with other medications or foods?

The antidepressant Tofranil (imipramine) may interact with several other medications: It's not recommended for people taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar) or tranylcypromine (Parnate), or for people who have taken one in the last 14 days.

Tell your doctor and pharmacist about every drug and supplement you take. In particular, if you take any of the following medications it may affect your dosage of Tofranil or mean you should be monitored carefully for side effects:
  • blood thinners such as warfarin (Coumadin)
  • antihistamines or asthma or cold medication
  • the antacid cimetidine (Tagamet)
  • heart medications for arrhythmia such as flecainide (Tambocor) and propafenone (Rythmol)
  • drugs for high blood pressure
  • Parkinson's medication such as levodopa (Sinemet, Larodopa)
  • mood stabilizers such as lithium (Eskalith, Lithobid)
  • selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft)
  • ADHD medication such as methylphenidate (Ritalin)
  • thyroid medications, muscle relaxants, tranquilizers, sleeping pills or drugs that treat nausea or seizures
If you’ve taken Prozac or Sarafem within the last five weeks, your doctor may tell you not to take Tofranil.

Tofranil isn't known to interact with any particular foods, but drinking alcohol while taking it can worsen drowsiness, a common side effect of the drug.

Continue Learning about Antidepressant

What should I know about antidepressants before I take them?
Dr. Darria Gillespie, MDDr. Darria Gillespie, MD
If you take an SRI, you should avoid alcohol. If you have had seizures, an SRI may not be a good op...
More Answers
How safe are tricyclic antidepressants for people with dementia?
Sarah N. Mourra, MDSarah N. Mourra, MD
Tricyclic antidepressants are used as second-line medications for depression in people with dementia...
More Answers
What medications or supplements interact with amitriptyline?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking a 5-HT3 antagonist, an antipsychotic, lithium, metaxalone, methylphenidate, metocl...
More Answers
How can I stop taking antidepressant medications safely?
Columbia University Department of SurgeryColumbia University Department of Surgery
Antidepressant medications need to be tapered and should only be done with consultation of your doct...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.