Can I stop taking desvenlafaxine if I feel better?

If you're taking desvenlafaxine (Pristiq) to treat depression, don't stop taking it without talking to your doctor first, even if you're feeling better. Quitting cold-turkey can lead to withdrawal symptoms such as sweating, dizziness, headache, nausea, irritability, anxiety, fatigue, trouble falling asleep or staying asleep, diarrhea and unusual dreams. If your symptoms of depression improve and you feel you don't need to keep taking desvenlafaxine, the best way to do it is to wean off the drug gradually, with your doctor's guidance.