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Can selective serotonin reuptake inhibitors (SSRIs) cause sexual problems?

Jan L. Shifren, MD
Reproductive Endocrinology
Selective serotonin reuptake inhibitors (SSRIs) -- which include fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil) -- can dampen desire and make it difficult to become aroused, sustain arousal, and achieve orgasm. Antidepressants can also cause vaginal dryness. An article in Psychiatric Annals suggests that as many as half of all people taking SSRIs experience some sexual problems.

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