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Can Savella interact with other medications or foods?

Savella (milnacipran) does not interact with any foods; in fact, taking the pill with food may reduce stomach problems. However, the drug, which is prescribed to treat fibromyalgia, does interact with several medications. Most dangerously, taking Savella with a monoamine oxidase inhibitor (MAOI), selective serotonin reuptake inhibitor (SSRI) or triptan drug can cause a life-threatening condition called serotonin syndrome. This reaction can also be triggered by combining Savella with another drug in its class -- that is, another selective serotonin and norepinephrine reuptake inhibitor (SNRI) -- or with certain nutritional supplements, especially tryptophan, 5-HTP or St. John's wort. Taking Savella along with a number of other drugs can cause this reaction too. Before starting Savella, tell your doctor about all your medicines (prescription and nonprescription), supplements and herbal remedies. Once you start taking Savella, do not take any new medication or supplement without talking to your doctor first.

Other medicines that may interact with Savella include epinephrine, norepinephrine, clomipramine, digoxin, clonidine, anticoagulants (such as warfarin), aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen, venlafaxine, sedatives, tranquilizers, sleeping pills, diuretics and seizure medications. Your doctor may need to change the dose of these medicines or watch you carefully for possible side effects caused by the combination.

Because Savella can cause sleepiness and affect your judgment or motor skills, you should avoid drinking alcohol while you're on it, since that can worsen these symptoms.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.