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Can antidepressants cause bone loss?

David Slovik, MD
Endocrinology Diabetes & Metabolism
Evidence is growing that serotonin reuptake inhibitors (SSRIs), a popular class of antidepressants, may cause bone thinning. The connection between depression and bone loss has been noted since the 1990s, but the precise nature of this association remained unclear for many years. However, an article in The Journal of Musculoskeletal and Neuronal Interactions that examined both laboratory and clinical evidence on the subject reported that SSRIs were linked to bone loss in four out of the five epidemiological studies analyzed.

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