What is the most important information I should know about trazodone?

Trazodone, like other antidepressant medications, may increase the risk for suicidal thoughts and behavior, especially in children, teenagers, and young adults. A person with increased suicidal tendencies may be more anxious, restless, hostile, or irritable, and may act impulsively or suffer panic attacks. Talk to your doctor immediately if you notice any changes in mood of a person taking trazodone. Do not take trazodone if you have a history of suicidal tendencies. Do not take trazodone if you have kidney or liver disease, heart disease, or have had a heart attack. Unless it is absolutely necessary, do not take trazodone if you are pregnant, breastfeeding, or trying to become pregnant. It is not known how trazodone affects a fetus or if this drug is passed through breast milk.
Before taking trazodone, tell your doctor all prescription medications, over-the-counter medications, vitamins, and herbal supplements you are taking. Be sure to include any medications that may alter the effects of trazodone, including sodium oxybate (GHB), HIV protease inhibitors, serotonin reuptake inhibitors (SSRIs), anticoagulants, hydantoins, penothiazines, carbamazepine, nefazodone, ethanol, digoxin, ginkgo biloba, and itraconazole. Do not drink alcohol or take drugs like muscle relaxers or sleep aids while on trazodone, as the combination may increase the risk of certain side effects. Don't drive or operate machinery until you know how you respond to trazodone.

For trazodone to be effective, it must be taken precisely as prescribed. Continue to take trazodone as directed even if you are feeling better.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.