What are the side effects of valproic acid in people with dementia?

Sarah N. Mourra, MD
The side effects or adverse effects from valproic acid (Depakote) in people with dementia involve rash, bleeding risk, dizziness and confusion, which can occur when levels become toxic. For this reason, blood levels of this medication should be frequently monitored to make sure that they are not reaching toxicity. With older adults, doctors tend to keep Depakote levels at the lower range, as long as it is working for the behavior. Doctors follow the behavior, not the drug level.
It’s important to know that sedation can occur with Depakote, as well as changes in liver enzymes, which the doctor will frequently monitor. In rare cases, Depakote can affect liver function, and that in itself can cause confusion and other issues somewhere down the line. If your older adult is experiencing new-onset confusion and Depakote has been recently started, bring this to the attention of the doctor sooner rather than later.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.