What should I know before taking Depakene?

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You should know that women who are pregnant, or who may become pregnant, should not take Depakene. The drug may cause severe birth defects or lower IQ in the child. Women of childbearing age should not take Depakene unless the drug is essential to the management of a medical condition.

If you or any of your blood relatives has a condition called urea cycle disorder (which interferes with the ability to turn food into energy), tell your doctor or pharmacist before taking this drug. You may not be able to take Depakene. Discuss all other major health problems or diseases you have had and any medications, vitamins, dietary supplements, or medicinal herbs that you take. If you take any of the following drugs you will likely still be able to take Depakene, but your doctor may want to adjust your dose: acyclovir (Zovirax); antidepressants, especially tricyclics such as amitriptyline and nortriptyline (Pamelor); blood-thinning medications such as warfarin (Coumadin); aspirin; clonazepam (Klonopin); diazepam (Valium); any medications for treating anxiety or any form of mental illness; other medications for preventing seizures, such as carbamazepine (Tegretol), ethosuximide (Zarontin), felbamate (Felbatol), lamotrigine (Lamictal), mephobarbital (Mebaral), phenobarbital, phenytoin (Dilantin), primidone (Mysoline), and topiramate (Topamax); meropenem (Merrem IV), rifampin (Rifadin); sedatives; sleeping pills and tranquilizers; tolbutamide; and zidovudine (Retrovir).