What medications interact with anticonvulsants?

Donna Hill Howes, RN
Family Practitioner

If you are taking an anticholinergic drug, metformin, primidone, rufinamide, a selective serotonin reuptake inhibitor, or valproate, topiramate may not be a good option for you.

If you are using azelastine nasal spray, a carbonic anhydrase inhibitor, a central nervous system depressant, a hormonal contraceptive, orphenadrine, paraldehyde, thalidomide, or ulipristal, topiramate can lead to side effects and should be avoided.

If you are taking lamotrigine, valproic acid may not be a good option for you.

If you are taking a salicylate, valproic acid and topiramate may not be good options for you.

If you take topiramate, you should avoid kava kava. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.