What are the side effects of phenobarbital?

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Side effects of phenobarbital include clumsiness, dizziness, drowsiness, confusion, nausea, headache, low blood pressure and slow heartbeat, slowed breathing, vomiting, and disorientation. Serious side effects include a severe allergic reactions (rash, hives, breathing trouble, chest tightness, swelling of mouth or face) and liver damage. Talk to your doctor about any side effects you experience. Call 911 for difficulty breathing, chest tightness, or swelling of  the lips, mouth, tongue or throat.