What are the risks or warnings with taking zonisamide?

Zonisamide may cause rare cases of metabolic acidosis, a condition where levels of a certain natural substance in the blood fall abnormally. Left untreated, metabolic acidosis may increase the risk for other medical problems, including kidney stones and bone problems that may lead to fractures. Untreated metabolic acidosis may also slow or stunt growth in children. Zonisamide can make it hard for you to sweat and cool down when it gets very hot. The drug can also cause changes in your mental health, such as depression or suicidal thoughts, panic attacks, agitation or restlessness, irritability, anxiety, difficulty falling or staying asleep, angry or violent behavior. Tell your family to call a doctor if you have any of these behavior changes.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.