Will primidone interact with other medicines I am taking?

Stacy Wiegman, PharmD

Pharmacy

Primidone could possibly interact with many drugs. Of these, 10 drugs need to be avoided completely. They are: - Dienogest

Dronedarone
Everolimus
Nilotinib
Nisoldipine
Pazopanib
Praziquantel
Ranolazine
Romidepsin
Tolvaptan

Primidone, along with all of the drugs listed above, belong to a group of drugs called “CYP3A4 inducers”. CYP3A4 is the abreviation for a specific enzyme involved in drug metabolism. Taking primidone with another CYP3A4 inducer decreases the amount of the second drug that is available to your body, which could lead to serious effects. Before starting primidone, you need to tell your doctor about all the medicines, both prescription and over-the-counter, that you are taking. He or she may need to change some of your medicines or change the doses that you are taking. This way, there will be less of a chance for potentially dangerous interactions.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.