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How can topiramate (Topomax) help with weight loss?

Craig B. Primack, MD
General Practice
Topiramate (Topamax) was originally approved in 1996 as a migraine-preventative treatment and seizure medication. Weight loss was initially seen as a side effect and it has now been studied directly for use in weight loss and in binge-eating disorder. The mechanism of action of topiramate is not entirely known. One mechanism that may contribute to its weight-loss effects is its effect on taste. Many patients taking this drug report certain foods taste different, especially diet colas. With altered taste sensations, some of the reward from eating certain foods may be altered.

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