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How does Topamax (topiramate) interact with other medications?

Using Topamax (topiramate) with ketorolac (Toradol) is not recommended, but may be required in some cases. If you need both medicines, your doctor may change the dosing for one or both. Using Topamax (topiramate) with certain medicines or supplements may increase the risk of certain side effects or interact with your treatment. If you take Topamax combined with any vitamins, nutritional supplements or herbs, your doctor may change dosing and may also need to monitor you for side effects.

Also, tell your doctor if you take acetazolamide, digoxin, amitriptyline, lithium, hydrochlorothiazide, dichlorphenamide or any antidepressants. Antihistamines, iron and any drugs for anxiety or mental illness should also be mentioned. Other drugs may also interact with Topamax: medications for irritable bowel disease, motion sickness, Parkinson's disease or urinary problems. Topamax may make your birth control work less effectively.

If you take carbamazepine, phenytoin, pioglitazone, risperidone, choline magnesium trisalicylate, choline salicylate, diflunisal, magnesium salicylate, salsalate, valproic acid, zonisamide, sedatives or tranquilizers for seizures, inform your doctor. If you are losing weight as a result of using Topamax, then talk to your doctor about increasing how many calories you consume per day. Do not start a diet or weight loss program while taking this drug without talking to your doctor first. Additionally, you should not eat a ketogenic diet (a low carbohydrate, high fat diet sometimes used to control seizures), the Atkins diet or any other low-carbohydrate or high-fat diet while on this medicine.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.