How should I take Topamax (topiramate)?

You should take Topamax exactly as directed by your doctor. It can be taken with or without food. The tablets should be swallowed whole (not chewed or crushed). The capsule can be swallowed whole or broken open and its contents can be sprinkled on about one teaspoon of nearly any soft food, like rice, ice cream, applesauce, custard, pudding or yogurt. Dosage for this drug is usually increased gradually, so for the first week you may only be taking one pill once a day. Over time, you likely will take one pill in the morning and one pill in the evening. This medicine should be taken at approximately the same times each day.

The exact dosage of Topiramate depends on the condition being treated. In order to avoid early side-effects (e.g. cognitive problems) the initial dosage is 25 daily for one week and then it is increased by 25 mg per week. Common dosages for maintenance treatment are 100 to 200 mg daily, taken in two divided doses. As the dose is increased the chance of side effects also increases. However most side effects encountered early in the course of therapy will improve with time. Therefore it is important to work closely with you doctor in order to find the most effective and well tolerated regimen.

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