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How does phenobarbital interact with other medications or foods?

Phenobarbital interacts with monoamine oxidase inhibitors (MAOIs), prescription and over-the-counter antihistamines, blood thinners, epilepsy drugs, steroids, tranquilizers, beta-adrenergic blockers, hypnotics, doxycycline, griseofulvin, narcotic pain relievers, phenytoin, sodium volproate, and valproic acid. It can also reduce the effectiveness of oral contraceptives such as estrogen, estradiol, and progesterone. Phenobarbital's effects are intensified when combined with alcohol and other narcotics, so this combination should be avoided.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.