How does phenobarbital interact with other medications or foods?

Phenobarbital interacts with monoamine oxidase inhibitors (MAOIs), prescription and over-the-counter antihistamines, blood thinners, epilepsy drugs, steroids, tranquilizers, beta-adrenergic blockers, hypnotics, doxycycline, griseofulvin, narcotic pain relievers, phenytoin, sodium volproate, and valproic acid. It can also reduce the effectiveness of oral contraceptives such as estrogen, estradiol, and progesterone. Phenobarbital's effects are intensified when combined with alcohol and other narcotics, so this combination should be avoided.

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