Ethotoin should not be combined with alcohol or tobacco. Certain medications may interfere with ethotoin or increase the side effects. The following medications can interact with ethotoin: Advil, Aleve, Amaryl, Bactrim, Carbatrol, Cataflam, Clozaril, Compazine, Cotrim, Coumadin, Cuprimine, Depakote, Depakene, Depen, Diabinese, Dilantin, Etrafon, FazaiClo, Felbatol, Glucotrol, Indocin, Janimine, Lodine, Levothroid, Loxitane, Ludiomil, Motrin, Mysoline, Navane, Naprosyn, Naproxen, Nebupent, Orap, Orinase, Pamelor, Priftin, Remeron, Septra, SMX-TMP, Sinequan, Synthroid, Tegretol, Thorazine, Ticlid, Tofranil, Trilafon, Tolinase or Voltaren. Anti-seizure medications, antibiotics, antidepressants, psychiatric disorder medications, anti-inflammatory drugs, muscle relaxers, narcotic pain relievers, antihistamines, sleep inducing medication, supplements and vitamins may interact. Ethotoin decreases the effectiveness of birth control, so non-hormonal contraception may be needed to prevent pregnancy (condoms, spermicides, etc).
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