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How does Dilantin-125 interact with other medications and food?

Dilantin, in the liquid suspension dosage form Dilantin-125, may interact with medications that increase blood levels of phenytoin, the active ingredient. These drugs include: certain sulfa drugs (antibiotics), estrogen hormone replacement drugs, certain sedatives and antidepressants, certain stomach acid reducers, methylphenidate (used to treat attention deficit hyperactivity disorder) and some phenothiazines (used for mental disorders and other problems). Other medications, including carbamazepine, sucralfate and molindone, may make Dilantin less effective. A variety of other medications may have a negative interaction with Dilantin. These include: certain steroids, antidepressants, antibiotics, anticonvulsants and others. Dilantin also interacts badly with alcohol, since side effects may be increased. Dilantin may also affect levels of certain substances in the blood, especially vitamin D and blood sugar. Enteral nutrition administered by a tube can interfere with the absorption of Dilantin.

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