How does Depakote react with other medications?

Any medication that causes drowsiness can worsen the amount of drowsiness you experience due to Depakote. These medications include sleeping pills, depression or anxiety medication, cold or allergy medication, muscle relaxers or narcotic medication. Depakote can also react negatively with other medications that treat seizures. Notify your doctor if you currently take any of these medications, along with: blood thinners such as warfarin; aspirin; topiramate (Topamax), tolbutamide (Orinase); diazepam (Valium); rifampin; zidovudine (Retrovir); ethosuximide (Zarontin). Other medications may interact with Depakote so discuss with your doctor any over-the-counter medications you take, along with any vitamins and herbal or dietary supplements you use. Tell your doctor if you consume alcohol, smoke or use any illegal drugs, as these may seriously react with Depakote.