How does Depacon interact with other medications or food?

Depacon has been known to interact with a number of other medications, the most important of which are carbamazepine, phenobarbital, phenytoin and any other drugs that increase levels of hepatic enzymes. These medications will increase the tolerance for Depacon, making a higher dosage necessary to achieve the desired effect. Several other drugs may also interact with Depacon. For example, aspirin may decrease the metabolism of Depacon. Carbapenem antibiotics may cause Depacon to be less effective at controlling seizures. Lower doses of amitriptyline or nortriptyline may be required when used with Depacon. Clonazepam may cause absence seizures to persist. Diazepam's metabolism is inhibited by Depacon. Ethosuximide's metabolism is inhibited by Depacon. Felbamate may decrease tolerance for Depacon. Lamotrigine, combined with Depacon, may produce skin reactions if the dosage of lamotrigine is too high. Topiramate, used in conjunction with Depacon, may cause hyperammonemia (high ammonia levels in the body) with or without encephalopathy (bad brain effects). Zidovudine's tolerance may be lowered when taken with Depacon.

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