How does Depakote ER interact with other medications?

Depakote ER may interact with a number of medications with varying results. Benzodiazepines, carbamazepine, erythromycin, felbamate, fluoxetine, guanfacine, isoniazid, ketoconazole, risperidone and salicylates can cause serious side effects when mixed with Depakote ER. Anticoagulants, barbiturates, ethosuximide, lamotrigine, methylphenidate, primidone, tolbutamide, certain antidepressants and zidovudine may also increase Depakote ER's side effects. Clonazepam may raise the seizure risk. Acyclovir, cancer medicines, certain antibiotics, cholestyramine, hydantoins, mefloquine, NSAID pain relievers, birth control pills and rifampin may interfere with the effectiveness of Depakote ER. It may also interact with herbal or dietary supplements, so talk to your doctor.

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