How is gabapentin used to treat hot flashes?

Donna Hill Howes, RN
Family Practitioner

Gabapentin (Neurontin, Gralise) was developed to treat seizures. It has also been used to help to reduce hot flashes, though it is not approved for this use by the FDA. Gabapentin, especially in doses of 900 mg a day, can reduce both the frequency and severity of hot flashes by about 50%. These effects apply not only to women going through natural menopause, but also to those with early menopause brought on by cancer chemotherapy.

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Dr. Julia Schlam Edelman
OBGYN (Obstetrician & Gynecologist)

Neurontin (gabapentin) is a medication prescribed to decrease nerve pain. Research shows that it also decreases hot flashes. In some cases, even in the absence of nerve pain, neurontin may be a good choice to decrease hot flashes. It is advisable to discuss this with your doctor to determine if it might be a good choice for you. It is usually prescribed to be taken at bedtime. At first the doctor may prescribe a lower dose, and then increase it every few weeks until you get relief from your hot flashes. It can also help you sleep better.

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