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Why is there a black box warning for Xarelto?

 Xarelto (rivaroxaban) carries two warnings on its label in a black-bordered box because of serious risks associated with the drug, which is used to prevent blood clotting. The warnings are:
  • Discontinuing Xarelto may increase the risk of dangerous blood clots and stroke if you have a type of abnormal heart rhythm known as nonvalvular atrial fibrillation. It may be necessary to switch to another anticoagulant.
  • Having spinal anesthesia, such as an epidural, or a spinal procedure, such as a spinal tap, may cause bleeding on or around the spine that can lead to long-term -- perhaps permanent -- paralysis.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.