Is taking warfarin and Lyrica at the same time safe?

If you already take warfarin and now your doctor wants you to take Lyrica, too, there's probably no reason for concern. Lyrica is a drug approved for the treatment of fibromyalgia and other conditions. Warfarin prevents blood clots. When the developers of Lyrica tested this drug in humans they found no evidence that it would cause problems if combined with warfarin. However, your doctor will want to monitor you closely all the same. Tell your physician about all symptoms you notice when you begin taking any medication.
Although there are no interactions identified in between warfarin and pregabalin, warfarin is notoriously sensitive to changes in medication. As usual, ensure that you and your doctor monitor your PTT times regularly and adjust your warfarin dose accordingly.