What are the side effects of nitrofurantoin (Macrobid)?

There are a number of possible side effects with nitrofurantoin. One harmless side effect is that the medication may discolor your urine a dark yellow or brown. This is nothing to be concerned about. Other common side effects include headaches and digestive tract disorders such as an upset stomach, gas, nausea, diarrhea, vomiting, and a lack of appetite.
Call your doctor if you experience severe side effects including:

- severe fatigue
- abnormal bruising or bleeding
- watery or bloody stools
- strange sensations in your hands or feet such as tingling, numbness, or burning
- a blue tinge to your skin or nails
- symptoms of lung disorders such as flu-like symptoms, trouble breathing, or persistent cough
- vision problems
- symptoms of liver disorders such as jaundiced (yellowish) skin or eyes, stomach pain, extreme nausea, lack of appetite, or pale-colored stool
- a butterfly-shaped rash on your cheeks or nose
- severe cramps
- disorientation
- severe diarrhea
- muscle or joint discomfort
- skin conditions such as blisters, swelling, redness, or peeling
- changes in your mood or mental functions
- long-lasting headache
- a persistent feeling of being run down
Talk to your doctor about any side effects that worry you or won't go away. Call 911 for emergency medical help if you have signs of an allergic reaction to nitrofurantoin, such as hives, trouble breathing, or swelling of your tongue, face, or throat.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.