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What is imipenem and cilastatin for injection?

Imipenem-cilastatin for injection is an antibiotic used to treat serious infections caused by susceptible bacteria. This antibiotic is composed of two active ingredients: imipenem, which is an antibiotic, and cilastatin, which inhibits a kidney enzyme from metabolizing the antibiotic completely. Imipenem-cilastatin for injection comes in two formulations that are administered differently. The intramuscular (IM) formulation is reconstituted with lidocaine (a numbing agent) and injected into a muscle from which it is slowly absorbed. The intravenous (IV) formulation is reconstituted with water and is administered by slow infusion through an IV line over one hour. Imipenem-cilastatin is used to treat infections of the female reproductive organs, lower respiratory system, stomach, skin, bones, joints, heart, urinary tract and others.

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